Credit: 6 ECTS.
When and where?
This lecture is given in the winter term:
Lectures every Tuesday, 14:00-15:30,
NEW ROOM FOR LECTURE AND EXERCISE: lecture hall 004 Hörsaal 1. New wooden building between mensa and chemistry building.
In class exercises every Wednesday, 14:00-17:00. Starting 24.10.18.
Lectures and exercises are held on the Garching campus of the TUM.
This module for students in bioinformatics, master students of Data Engineering and Analytics, and master students of Biomedical Computing teaches methodologies and good practice of data science using R.
The lecture is structured into three main parts, covering the major steps of data analysis:
1. Get the data: how to fetch, and manipulate real-world datasets. How to structure them ("tidy data") to most conveniently work with them.
2. Look at the data: basic and advanced visualization techniques (grammar of graphics, unsupervised learning) will allow students to navigate and identify interesting signal in large and complex datasets and formulate hypotheses.
3. Conclude: concepts of statistical testing will allow concluding about the raised hypotheses. Also methods from supervised learning will allow to model data and build accurate predictors.
Each week, the lecture is accompanied with exercises. During the exercises, combinations of the concepts seen during the lecture will allows performing more involved data analysis tasks. Students generate report that embed code and analysis. Two more advanced case studies complement the course. Many examples will stem from applications in genomics, but no pre-requisite in this domain is necessary.
Experience with programming of any language. The theoretical aspects of data analysis are kept low in this module. However, basics in probabilities are required. See our companion module "Statistical modelling and machine learning" to complement it.
R for Data Science, by Garrett Grolemund and Hadley Wickham
Modern Dive, by Chester Ismay and Albert Y. Kim
Introduction to Data Science, by Rafael A. Irizarry
Bring a laptop with RStudio installed, a free programming interface for the R language.
R programming basics, report generation with R markdown
Importing, cleaning and organizing data (tidy data)
Plotting and Grammar of graphics
Unsupervised learning (hierarchical clustering, k-means, PCA)
Drawing robust interpretations (empirical testing by sampling, classical statistical tests)
Supervised learning (regression, classification, cross-validation)
The final exam is a 2 hours written exam. The mark will be the one of the final exam plus bonus points for the home works and case studies.
This lecture is given by a team of scientists with long experience in high-dimensional data analysis in the field of genomics:
Prof. Julien Gagneur and members of his lab.
Dr. Matthias Heinig, Group leader, Institute of Computational Biology, Helmholtz center